ISSN 1308-7649 | E-ISSN 2148-3817
1 Department of Otolaryngology, Head and Neck Surgery, Bayındır Hospital, İstanbul Turkey  
2 Department of Otolaryngology, Head and Neck Surgery, Ümraniye Training and Research Hospital, İstanbul, Turkey  
3 Department of Otolaryngology, Head and Neck Surgery, İstanbul Okmeydanı Training and Research Hospital, İstanbul, Turkey  
4 Department of Medical Biochemistry, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey  
J Int Adv Otol ; : -

Abstract

OBJECTIVE: Benign paroxysmal positional vertigo (BPPV) is the most frequently peripheral vestibular disorder, especially in older patients suffering from vertigo. The brief vertigo attacks and imbalance symptoms of BPPV are caused by freely floating otoconia within the semicircular canals. The aim of this prospective study was to evaluate the role of oxidative stress, using native thiol/disulfide (SH/SS) homeostasis as a novel indicator, in the etiology of BPPV.

 

MATERIALS and METHODS:  The 62 participants in the study included 31 patients with BPPV and, as the control group, 31 healthy individuals without any cochleovestibular disorders.

 

RESULTS: Patients with BPPV initially had significantly lower native SH levels and significantly lower SH/total thiol (TT) ratios, as well as significantly higher SS/SH and SS/TT ratios than the control group. After successful treatment of their vertigo, confirmed based on the results of the second blood sample, BPPV patients still had lower SH levels, and SH/TT ratios, and significantly higher SS/SH and SS/TT ratios compared with the control group.

 

CONCLUSION: Our results suggest a role for oxidative stress in the development of BPPV, through both calcium metabolism and the direct toxic effects of free oxygen radicals, including the triggering of apoptosis.

 

Cite this article as: Şahin E, Deveci İ, Dinç ME, Yayla Özker B, Biçer C, Erel Ö. Oxidative status in patients with benign paroxysmal positional vertigo. J Int Adv Otol 2017. DOI: 10.5152/iao.2017.4756

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