ISSN 1308-7649 | E-ISSN 2148-3817
1 Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine.,Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan  
2 Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan  
3 Toyota Josui Mental Clinic, Aichi, Japan., Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan  
4 Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology;Department of Otorhinolaryngology, Aichi Medical University School of Medicine, Aichi, Japan  
5 Section of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan  
6 Section of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology.;Faculty of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan  
7 Section of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology;. Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan  
8 Ichinomiya Medical Treatment and Habilitation Center, Aichi, Japan  
J Int Adv Otol ; : -

Abstract

OBJECTIVES: The pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk.


MATERIALS and METHODS
: We compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene.


RESULTS
: Under the additive model of inheritance, UCP2 polymorphisms showed significant association with a SD risk. The OR was 1.468 (95% confidence interval, 1.056–2.040) with an adjustment for any past history, such as diabetes, dyslipidemia, or hypertension, and for age and sex.


CONCLUSION
: Our results imply that the UCP2 (rs660339) polymorphism has a significant association with the risk of developing SD.


Cite this article as
: Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, et al. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. J Int Adv Otol 2018; DOI: 10.5152/iao.2018.5442.

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AVES | Copyright © 2018 The European Academy of Otology and Neurotology | Latest Update: 16.08.2018