ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy
1 Istanbul Training and Research Hospital, Otorhinolaryngology Department, Istanbul, Turkey  
2 Inonu University, Medical Faculty, Histology and Embryology, Malatya, Turkey  
3 Istanbul Training and Research Hospital, Electrophysiology, Istanbul, Turkey  
4 Istanbul University, Cerrahpasa Medical Faculty, Neurology, Istanbul, Turkey  
J Int Adv Otol ; : -
DOI: 10.5152/iao.2018.3273
Key Words: Facial nerve, axotomy, neurrorhaphy, compound muscle action potential, regeneration

Objectives: To investigate the effects of topical and systemic administrations of melatonin and dexamethasone on facial nerve regeneration.


Materials and Methods: 50 male albino Wistar rats underwent facial nerve axotomy and neurrorhaphy. Animals were divided into 5 groups: Control, topical melatonin, systemic melatonin, topical dexamethasone and systemic dexamethasone. Nerve conduction studies were performed preoperatively and at 3, 6, 9 and 12 weeks after drug administrations. Amplitude and latency of the compound muscle action potentials were recorded. Coapted facial nerves were investigated under light and electron microscopy. Nerve diameter, axon diameter and myelin thickness were recorded quantitatively.

Results: Amplitudes decreased and latencies increased in both melatonin and dexamethasone groups. At last examination, electrophysiological evidence of facial nerve degeneration was not significantly different between the groups. Histopathological investigations revealed largest nerve diameter in melatonin groups followed by dexamethasone and control groups (p<0.05). Axon diameter of the control group was smaller than the melatonin (topical and systemic) and topical dexamethasone groups (p<0.05). Melatonin groups had almost normal myelin ultrastructure.


Conclusion: Electrophysiological investigation did not reveal any potential benefit of dexamethasone and melatonin in contrast to histopathological examination , which revealed beneficial effects of especially melatonin. These agents may increase the regeneration of facial nerve, but electrophysiological evidence may delay.


Cite this article as: Edizer DT, Dönmez Z, Gül M, Yiğit Ö, Yiğitcan B, Adatepe T, et al. Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy. J Int Adv Otol 2018; DOI: 10.5152/iao.2018.3273


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