The Journal of International
Advanced Otology
Original Article

Comparison of Endoplasmic Reticulum Stress Messenger Ribonucleic Acid Expression Between Chronic Otitis Media With and Without Cholesteatoma

1.

Department of Otorhinolaryngology – Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

2.

Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

3.

Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea

4.

Medical Science Research Institute, Kyung Hee University Medical Center, Seoul, Republic of Korea

J Int Adv Otol 2023; 19: 271-276
DOI: 10.5152/iao.2023.21182
Read: 788 Downloads: 370 Published: 01 August 2023

BACKGROUND: We evaluated and compared the role of endoplasmic reticulum stress in chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma.

METHODS: The messenger ribonucleic acid expression of endoplasmic reticulum stress was measured and compared between chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma according to the presence or absence of bacteria, type of hearing loss, ossicle destruction, and facial canal dehiscence.

RESULTS: The expression of immunoglobulin heavy chain-binding protein messenger ribonucleic acid was higher in the chronic otitis media without cholesteatoma group than in the chronic otitis media with cholesteatoma group, and Protein kinase RNA (PKR)-like endoplasmic reticulum kinase and activating transcription factor 6 messenger ribonucleic acid expression were higher in the chronic otitis media with cholesteatoma group than in the chronic otitis media without cholesteatoma group.

CONCLUSION: Endoplasmic reticulum stress messenger ribonucleic acids were expressed in both chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma. The levels of expression of endoplasmic reticulum stress messenger ribonucleic acids differed according to clinical features, suggesting that different endoplasmic reticulum stress pathways are involved in the pathophysiology of different types of chronic otitis media.

Cite this article as: Woong Kang D, Jun Kim Y, Soo Kim S, et al. Comparison of endoplasmic reticulum stress messenger ribonucleic acid expression between chronic otitis media with and without cholesteatoma. J Int Adv Otol. 2023;19(4):271-276.

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