The Journal of International
Advanced Otology
Case Report

Malignant Degeneration of Squamous Papilloma Involving the Temporal Bone


Department of Otoloaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, College of Medicine, AR, USA


Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA


Department of Otoloaryngology-Head and Neck Surgery, University of Chicago Pritzker School of Medicine, IL, USA

J Int Adv Otol 2014; 10: 190-193
DOI: 10.5152/iao.2014.85
Read: 1123 Downloads: 541 Published: 03 September 2019


We report a rare case of malignant degeneration of a squamous papilloma to squamous cell carcinoma. A 47-year-old female presented at our tertiary referral center with squamous papilloma of the middle ear that transformed into advanced-stage (T4N0M0) squamous cell carcinoma of the temporal bone, with involvement of the facial nerve, labyrinth, temporomandibular joint, sigmoid sinus, and dura of the middle and posterior cranial fossae. An extended subtotal temporal bone resection, selective neck dissection, and superficial parotidectomy were performed, followed by concurrent radiation therapy and chemotherapy. At 9 months post-surgery, a clinical exam and imaging suggested disease-free status. Although extremely rare, malignant transformation of a benign squamous papilloma of the temporal bone can occur. These lesions should be managed by gross total tumor resection, with judicious preservation of vital structures, followed by close tumor surveillance. 

EISSN 2148-3817