The Journal of International
Advanced Otology
Original Articles

Progressive Ototoxicity of Baby Shampoo As An Antifog Agent: An Experimental Study

1.

Department of Otorhinolaryngology, Istanbul Medeniyet University Faculty of Medicine, İstanbul, Türkiye

2.

Department of Otorhinolaryngology, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, İstanbul, Türkiye

3.

Department of Audiology, İstanbul Medeniyet University Faculty of Health Sciences, İstanbul, Türkiye

4.

Department of Audiology, Trakya University Faculty of Health Sciences, Edirne, Türkiye

5.

Mirko Tos Ear and Hearing Research Center, Edirne, Türkiye

6.

Department of Pathology Laboratory Techniques, Trakya University Vocational School of Health Services, Edirne, Türkiye

7.

Department of Otorhinolaryngology, Derince Research and Training Hospital, Kocaeli, Türkiye

J Int Adv Otol 2025; 21: 1-9
DOI: 10.5152/iao.2025.241526
Read: 83 Downloads: 34 Published: 25 March 2025

BACKGROUND: Endoscopes play an important role in otologic surgery. Baby shampoos, known for their hypoallergenic, anti-irritant, and antifogging properties, are increasingly being used. The purpose of this study was to evaluate the safety and ototoxic effects of baby shampoo in an animal model using both electrophysiological and histological methods.

METHODS: Twenty-eight male Sprague–Dawley rats were divided into 4 groups: 7 control (group 1), 7 saline (group 2), 7 isopropyl alcohol (70%) + chlorhexidine (2%) antiseptic (group 3), and 7 baby shampoo (group 4). Baseline hearing was assessed by auditory brainstem response (ABR). All groups except the control received 3 doses of their respective substances by intratympanic injection. Auditory brainstem response measurements were performed on day 7 and day 21, after which the temporal bones were dissected. Histological evaluation of the cochlea and vascular endothelial growth factor (VEGF) immunoreactivity studies were performed.

RESULTS: Baseline hearing thresholds were similar and within normal limits. On days 7 and 21, hearing thresholds were significantly impaired at all frequencies in the experimental groups. In particular, groups 3 and 4 had higher thresholds than the other groups. Baby shampoo caused significant damage to outer hair cells and sustentacular cells and decreased VEGF immunoreactivity in the stria vascularis, spiral ligament, and organ of Corti.

CONCLUSION: Baby shampoo was found to progressively impair hearing over time, indicating its potential to cause long-term ototoxicity.

Cite this article as: Mutlu A, Bakici B, Yasemin Gunduz A, et al. Progressive ototoxicity of baby shampoo as an antifog agent: an experimental study. J Int Adv Otol. 2025, 21(2), 1526, doi: 10.5152/iao.2025.241526.

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