The Journal of International Advanced Otology
Original Article

The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere’s Disease-A Preliminary Study

1.

Department of Otolaryngology, Sichuan University, West China Hospital, Chengdu, Sichuan, China

J Int Adv Otol 2019; 15: 130-134
DOI: 10.5152/iao.2019.5076
Read: 212 Downloads: 12 Published: 03 September 2019

Abstract

OBJECTIVES: To investigate the correlation between KCNE gene family and Meniere’s disease (MD) in the Chinese population.

 

MATERIALS and METHODS: This study analyzed the single-nucleotide polymorphism (SNP) of KCNE1 and KCNE3 genes between the MD group and the control group and between the familial Meniere’s disease (FMD) group and the sporadic Meniere’s disease (SMD) group.

 

RESULTS: A total of 653 C/T SNPs of KCNE1 had a statistical difference between the FMD and SMD groups (p=0.0082<0.05); 492 A/C SNPs of KCNE3 were statistically different between the FMD group and the control group (genotype p=0.037<0.05 and allele p=0.006<0.05).

 

CONCLUSION: SNPs of KCNE1 and KCNE3 gene mutations were, respectively, different between the SMD and FMD groups. KCNE3 gene polymorphism was key to FMD disease, whereas KCNE1 was more important to the onset of SMD.

 

Cite this article as: Dai Q, Wang D, Zheng H. The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere’s Disease-A Preliminary Study. J Int Adv Otol 2019; 15(1): 130-4.

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ISSN1308-7649 EISSN 2148-3817