ISSN 1308-7649 | E-ISSN 2148-3817
1 Department of ENT, Adnan Menderes University School of Medicine, Aydın, Turkey  
2 Department of Biochemistry, Adnan Menderes University School of Medicine, Aydın, Turkey  
J Int Adv Otol ; : -


OBJECTIVES: The aim of this prospective clinical study was to examine the negative effect of drilling by measuring peripheral Otolin-1 levels as a potential biomarker.


MATERIALS and METHODS: Patients who underwent mastoidectomy due to chronic otitis media were included in the study. Otolin-1 levels were measured preoperatively and 6 h postoperatively, and total drilling time was noted. Preoperative serum Otolin-1 levels in 31 patients were compared with those in31 age- and sex-matched healthy individuals. Pre- and postoperative serum Otolin-1 levels were also compared.


RESULTS: Tympanoplasty was performed through canal wall-down (n=17) and wall-up mastoidectomy (n=14) in our sample. The mean duration of drilling was 52.7±13.8min. Preoperative serum Otolin-1 levels were significantly lower in patients than in healthy controls (21.0±3.0 vs. 23.5±3.9 pg/mL, p=0.006). We also found significantly higher postoperative serum Otolin-1 levels than preoperative levels (21.0±3.0 vs. 27.0±6.9 pg/mL, p<0.001). An increase in serum Otolin-1 levels during surgery was independently associated with drilling time in multivariate linear regression analysis (r=0.309, p<0.001).


CONCLUSION: A nearly postoperative increase in serum Otolin-1 levels after mastoidectomy was independently associated with drilling time. We show that serum Otolin-1 levels may be used to indicate inner ear trauma in clinical practice in the future.


Cite this article as: Doğan M, Şahin M, Kurtulmuş Y. Otolin-1, as a Potential Marker for Inner Ear Trauma after Mastoidectomy. J Int Adv Otol 2019; DOI: 10.5152/iao.2019.5155.

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