ISSN 1308-7649 | E-ISSN 2148-3817
Original Article
Assessment of the Effectiveness of Quercetin on Cisplatin-Induced Ototoxicity in Rats
1 Department of Otolaryngology, Derince Tranining and Research Hospital, Kocaeli, Turkey  
2 Department of Otolaryngology, Head and Neck Surgery, Erciyes University School of Medicine, Kayseri, Turkey  
3 Clinic of Otolaryngology, Kayseri City Hospital, Kayseri, Turkey  
4 Department of Histology, Erciyes University School of Medicine, Kayseri, Turkey  
J Int Adv Otol 2019; 15: 229-236
DOI: 10.5152/iao.2019.5902
Key Words: cisplatin, ototoxicity, antioxidants, flavonoids, quercetin


OBJECTIVES: This study aimed to evaluate the effect of quercetin on cochlear function and morphology, and its possible protective effect against acute cisplatin-induced ototoxicity in rats.


MATERIALS and METHODS: This prospective and controlled animal study was conducted on Wistar albino rats divided into four groups. Otoacoustic emission measures were performed three days after the first infiltration in Group 1 (saline), 2 (cisplatin), and 3 (quercetin). This interval was five days for Group 4 (cisplatin+quercetin). At the end of the study, the rats were decapitated with deep anesthesia, and histological changes in the cochleas were observed by light microscopy.


RESULTS: Group 2 (cisplatin) revealed significant differences between the first and second measures in all frequencies. When compared to other group, the difference of the changes in Group 2 statistically significantly decreased, especially in higher frequencies. Morphologically, there were no acute changes in Group 1 and Group 3. Outer hair cell loss and the degeneration of stria vascularis and spiral ganglion were observed in both Groups 2 and 4; the damages in the latter were lesser.


CONCLUSION: Quercetin does not have negative effect on cochlea, and it has protective effect on cisplatin-induced ototoxicity.


Cite this article as: Gündoğdu R, Erkan M, Aydın M, Sönmez MF, Vural A, Kökoğlu K, et al. Assessment of the Effectiveness of Quercetin on Cisplatin-Induced Ototoxicity in Rats. J Int Adv Otol 2019; 15(2): 229-36.

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