Original Article

Vol. 14 No. 2 (2018): The Journal of International Advanced Otology

The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population

Main Article Content

Wen-Yi Lin
Hua-Ling Yang
Hsun-Mo Wang
Kuen-Yao Ho
Ning-Chia Chang
Chia-Yen Dai
Chen-Yu Chien
Meng-Hsuan Hsieh

Abstract

Abstract


 



OBJECTIVES: Age-related hearing impairment (ARHI) is a major disability among the elderly. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor 7 (GRM7) gene with ARHI in an elderly population in Taiwan.





MATERIALS and METHODS
: This was a community-based study performed in a metropolitan hospital. Participants ≥65 years of age were recruited. Participants with a pure tone average (PTA) of speech frequencies in the better ear of >35 decibel hearing level (dBHL) were classified into the case group, whereas those with PTA ≤25 dBHL were classified into the control group. The association of SNPs rs11928865, rs1353828, rs9814809, and rs9880404 with ARHI was analyzed.





RESULTS
: In 106 cases and 190 controls, alleles of all SNPs were found not to be associated with ARHI. The genotype of rs9880404 was found to be associated with ARHI in a dominant pattern, but the genotypes of rs11928865, rs1353828, and rs9814809 were found not to be associated with ARHI.





CONCLUSION
: GRM7 SNPs are associated with susceptibility to ARHI, but the significance of this finding in a Taiwanese population differed from that observed in European studies. Further studies may help to determine Taiwanese (Asian)-specific SNPs associated with ARHI.





Cite this article as
: Chang NC, Dai CY, Lin WY, Yang HL, Wang HM, Chien CY, et al. The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population. J Int Adv Otol 2018; 14(2): 170-5.

Article Details