Original Article

Vol. 19 No. 2 (2023): The Journal of International Advanced Otology
DOI: https://doi.org/10.5152/iao.2023.21523%20

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Published: Mar 27, 2023
Keywords:
Sudden sensorineural hearing loss, lipoprotein-associated phospholipase A2, endothelial progenitor cells, hearing loss, pathogenesis

Main Article Content

Chao Dong
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Dong Yang
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Peng Zhang
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Xin Li
Department of Otolaryngology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
Sitong Guo
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China

Sudden Sensorineural Hearing Loss Is Related to Endothelial Progenitor Cells and Lipoprotein-Associated Phospholipase A2

Main Article Content

Chao Dong
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Dong Yang
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Peng Zhang
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China
Xin Li
Department of Otolaryngology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
Sitong Guo
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China

Abstract

BACKGROUND: This study aimed to investigate the correlation between lipoprotein-associated phospholipase A2, endothelial progenitor cells, and sudden sensorineural hearing loss.



METHODS: The number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels collected from peripheral blood samples were measured and compared between sudden sensorineural hearing loss group and control group.



RESULTS: The number of endothelial progenitor cells was reduced in sudden sensorineural hearing loss group compared to control group (38.88 ± 10.73 in sudden sensorineural hearing loss group vs. 77.14 ± 8.56 in control group, P <.01). The lipoprotein-associated phospholipase A2 level was markedly increased in sudden sensorineural hearing loss group compared to control group (244.94 ± 59.547 in sudden sensorineural hearing loss group vs. 189.00 ± 50.987 in control group, P <.05).



CONCLUSION: The number of endothelial progenitor cells was decreased and lipoprotein-associated phospholipase A2 levels were increased in sudden sensorineural hearing loss patients. Changes in the number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels may be involved in the pathogenesis of sudden sensorineural hearing loss.



Cite this article as: Dong C, Yang D, Zhang P, Guo S, Li X. Sudden sensorineural hearing loss is related to endothelial progenitor cells and lipoprotein-associated phospholipase A2. J Int Adv Otol. 2023;19(2):76-80.


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