The Journal of International Advanced Otology
Original Article

Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss

1.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine;Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan

2.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan

3.

Toyota Josui Mental Clinic, Aichi, Japan.,Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan

4.

Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology;Department of Otorhinolaryngology, Aichi Medical University School of Medicine, Aichi, Japan

5.

Section of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan

6.

Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan

7.

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan

8.

Ichinomiya Medical Treatment and Habilitation Center, Aichi, Japan

J Int Adv Otol 2018; 14: 166-169
DOI: 10.5152/iao.2018.5442
Read: 765 Downloads: 125 Published: 03 September 2019

Abstract

 

OBJECTIVES: The pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk.


MATERIALS and METHODS
: We compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene.


RESULTS
: Under the additive model of inheritance, UCP2 polymorphisms showed significant association with a SD risk. The OR was 1.468 (95% confidence interval, 1.056–2.040) with an adjustment for any past history, such as diabetes, dyslipidemia, or hypertension, and for age and sex.


CONCLUSION
: Our results imply that the UCP2 (rs660339) polymorphism has a significant association with the risk of developing SD.


Cite this article as
: Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, et al. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. J Int Adv Otol 2018; 14(2): 166-9.

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ISSN1308-7649 EISSN 2148-3817