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Original Article

Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss

Yusuke Koide 1 , Masaaki Teranishi 2 , Saiko Sugiura 3 , Yasue Uchida 4 , Naoki Nishio 2 , Ken Kato 2 , Hironao Otake 2 , Tadao Yoshida 2 , Rei Otsuka 5 , Fujiko Ando 5 , Hiroshi Shimokata 6 , Yasuhisa Hasegawa 7 , Tsutomu Nakashima 8 , Michihiko Sone 2
1.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine;Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan

2.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan

3.

Toyota Josui Mental Clinic, Aichi, Japan.,Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan

4.

Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology;Department of Otorhinolaryngology, Aichi Medical University School of Medicine, Aichi, Japan

5.

Section of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan

6.

Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan

7.

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan

8.

Ichinomiya Medical Treatment and Habilitation Center, Aichi, Japan

J Int Adv Otol 2018; 14: 166-169
DOI: 10.5152/iao.2018.5442
Keywords : Genetic polymorphisms, sudden deafness, uncoupling protein 2
Read: 3035 Downloads: 1028 Published: 03 September 2019
Volume 14, Issue 2, August 2018
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Abstract

 

OBJECTIVES: The pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk.


MATERIALS and METHODS: We compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene.


RESULTS: Under the additive model of inheritance, UCP2 polymorphisms showed significant association with a SD risk. The OR was 1.468 (95% confidence interval, 1.056–2.040) with an adjustment for any past history, such as diabetes, dyslipidemia, or hypertension, and for age and sex.


CONCLUSION: Our results imply that the UCP2 (rs660339) polymorphism has a significant association with the risk of developing SD.


Cite this article as: Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, et al. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. J Int Adv Otol 2018; 14(2): 166-9.

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