The Journal of International Advanced Otology
Original Article

The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population

1.

Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine, Health Management Center, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan

2.

Department of Internal Medicine, Kaohsiung Medical University School of Medicine;Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

3.

Health Management Center, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan

4.

Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

5.

Clinic of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan

6.

Department of Otorhinolaryngology, Kaohsiung Medical University School of Medicine;Clinic of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan

7.

Health Management Center, Kaohsiung Municipal Hsiao-Kang Hospital.,Department of Internal Medicine, Kaohsiung Medical University School of Medicine, Kaohsiung, Taiwan

J Int Adv Otol 2018; 14: 170-175
DOI: 10.5152/iao.2018.5109
Read: 128 Downloads: 12 Published: 03 September 2019

Abstract

 

OBJECTIVES: Age-related hearing impairment (ARHI) is a major disability among the elderly. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor 7 (GRM7) gene with ARHI in an elderly population in Taiwan.


MATERIALS and METHODS
: This was a community-based study performed in a metropolitan hospital. Participants ≥65 years of age were recruited. Participants with a pure tone average (PTA) of speech frequencies in the better ear of >35 decibel hearing level (dBHL) were classified into the case group, whereas those with PTA ≤25 dBHL were classified into the control group. The association of SNPs rs11928865, rs1353828, rs9814809, and rs9880404 with ARHI was analyzed.


RESULTS
: In 106 cases and 190 controls, alleles of all SNPs were found not to be associated with ARHI. The genotype of rs9880404 was found to be associated with ARHI in a dominant pattern, but the genotypes of rs11928865, rs1353828, and rs9814809 were found not to be associated with ARHI.


CONCLUSION
: GRM7 SNPs are associated with susceptibility to ARHI, but the significance of this finding in a Taiwanese population differed from that observed in European studies. Further studies may help to determine Taiwanese (Asian)-specific SNPs associated with ARHI.


Cite this article as
: Chang NC, Dai CY, Lin WY, Yang HL, Wang HM, Chien CY, et al. The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population. J Int Adv Otol 2018; 14(2): 170-5.

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ISSN1308-7649 EISSN 2148-3817