The Journal of International Advanced Otology
Original Article

Otolin-1, as a Potential Marker for Inner Ear Trauma after Mastoidectomy

1.

Department of ENT, Adnan Menderes University School of Medicine, Aydın, Turkey

2.

Department of Biochemistry, Adnan Menderes University School of Medicine, Aydın, Turkey

J Int Adv Otol 2019; 15: 200-203
DOI: 10.5152/iao.2019.5155
Read: 249 Downloads: 47 Published: 03 September 2019

Abstract

 

OBJECTIVES: The aim of this prospective clinical study was to examine the negative effect of drilling by measuring peripheral Otolin-1 levels as a potential biomarker.

 

MATERIALS and METHODS: Patients who underwent mastoidectomy due to chronic otitis media were included in the study. Otolin-1 levels were measured preoperatively and 6 h postoperatively, and total drilling time was noted. Preoperative serum Otolin-1 levels in 31 patients were compared with those in31 age- and sex-matched healthy individuals. Pre- and postoperative serum Otolin-1 levels were also compared.

 

RESULTS: Tympanoplasty was performed through canal wall-down (n=17) and wall-up mastoidectomy (n=14) in our sample. The mean duration of drilling was 52.7±13.8min. Preoperative serum Otolin-1 levels were significantly lower in patients than in healthy controls (21.0±3.0 vs. 23.5±3.9 pg/mL, p=0.006). We also found significantly higher postoperative serum Otolin-1 levels than preoperative levels (21.0±3.0 vs. 27.0±6.9 pg/mL, p<0.001). An increase in serum Otolin-1 levels during surgery was independently associated with drilling time in multivariate linear regression analysis (r=0.309, p<0.001).

 

CONCLUSION: A nearly postoperative increase in serum Otolin-1 levels after mastoidectomy was independently associated with drilling time. We show that serum Otolin-1 levels may be used to indicate inner ear trauma in clinical practice in the future.

 

Cite this article as: Doğan M, Şahin M, Kurtulmuş Y. Otolin-1, as a Potential Marker for Inner Ear Trauma after Mastoidectomy. J Int Adv Otol 2019; 15(2): 200-3.

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ISSN1308-7649 EISSN 2148-3817