The Journal of International
Advanced Otology
Original Article

Sudden Sensorineural Hearing Loss Is Related to Endothelial Progenitor Cells and Lipoprotein-Associated Phospholipase A2

1.

Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China

2.

Department of Otolaryngology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China

J Int Adv Otol 2023; 19: 76-80
DOI: 10.5152/iao.2023.21523
Read: 747 Downloads: 363 Published: 27 March 2023

BACKGROUND: This study aimed to investigate the correlation between lipoprotein-associated phospholipase A2, endothelial progenitor cells, and sudden sensorineural hearing loss.

METHODS: The number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels collected from peripheral blood samples were measured and compared between sudden sensorineural hearing loss group and control group.

RESULTS: The number of endothelial progenitor cells was reduced in sudden sensorineural hearing loss group compared to control group (38.88 ± 10.73 in sudden sensorineural hearing loss group vs. 77.14 ± 8.56 in control group, P <.01). The lipoprotein-associated phospholipase A2 level was markedly increased in sudden sensorineural hearing loss group compared to control group (244.94 ± 59.547 in sudden sensorineural hearing loss group vs. 189.00 ± 50.987 in control group, P <.05).

CONCLUSION: The number of endothelial progenitor cells was decreased and lipoprotein-associated phospholipase A2 levels were increased in sudden sensorineural hearing loss patients. Changes in the number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels may be involved in the pathogenesis of sudden sensorineural hearing loss.

Cite this article as: Dong C, Yang D, Zhang P, Guo S, Li X. Sudden sensorineural hearing loss is related to endothelial progenitor cells and lipoprotein-associated phospholipase A2. J Int Adv Otol. 2023;19(2):76-80.

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